CORDIS Project
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This project investigates the role of NMDA glutamate receptors in schizophrenia by examining changes in receptor assembly, alternative splicing, and trafficking in an animal model. The goal is to understand how these processes are altered in schizophrenia and to explore potential cognitive-enhancing peptides for treatm…
The pathophysiological mechanisms causing schizophrenia are not well known.
Schizophrenia is characterized by symptoms such as hallucinations, emotional isolation and cognitive deficits.
Altered neurotransmission through the glutamate transmitter system has been linked to this devastating psychiatric illness.
In particular, observations that functional antagonism of the N-methyl-D-apartate (NMDA) glutamate receptor by phencyclidine (PCP) worsens all symptoms in patients and induces a schizophren…
KOBENHAVNS UNIVERSITET
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