CORDIS Project
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This research focuses on understanding how different ligands affect the conformational changes in the cannabinoid receptor CB2, which is involved in immune response and pain sensation. The project utilizes NMR spectroscopy to study these dynamic processes.
GPCRs are involved in a variety of biological and pathological processes ranging from metabolic, neurological and immune system disorders to inflammation.
The members of this large family of proteins can be activated by various stimuli including hormones, neurotransmitters, ions, odorants and light.
The location of GPCRs on the cell surface and their roles as initiators in many cellular signaling pathways make them predominant drug targets.
Around 30% of all drugs on the current therapeutic mark…
PAUL SCHERRER INSTITUT
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