CORDIS Project
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This project investigates how specific proteins, known as molecular chaperones, disassemble toxic protein aggregates linked to neurodegenerative diseases. Using advanced Nuclear Magnetic Resonance techniques, it aims to understand the interactions between chaperones and their substrates, ultimately contributing to cell…
Molecular chaperones are a diverse group of proteins critical to maintaining cellular homeostasis.
Aside from protein refolding, it has recently been discovered that certain combinations of human chaperones can break apart toxic protein aggregates and even amyloids that have been linked to a host of neurodegenerative diseases.
The first chaperones in this disaggregation reaction that are responsible for recognizing and performing initial remodeling of aggregates, are members of the Hsp40 (DnaJ)…
WEIZMANN INSTITUTE OF SCIENCE
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