CORDIS Project
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This project investigates the nonsense-mediated mRNA decay (NMD) pathway, which is crucial for regulating gene expression and preventing the production of faulty proteins. The research aims to clarify the interactions of key NMD factors and their roles in genetic disorders and cancer.
Nonsense-mediated mRNA decay (NMD) is an important quality control pathway conserved throughout all eukaryotes: mRNAs which contain premature stop codons (PTC) are detected and committed to accelerated decay to protect the cell from deleterious effects of truncated proteins. NMD also controls abundance of many wild-type genes that contain features recognized by the NMD machinery.
Due to the important tasks of NMD, its proper functioning is essential for embryogenesis in vertebrates.
Furthermore,…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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