CORDIS Project
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This research focuses on the role of NMDA receptors in autism and related disorders, particularly in the context of Mecp2 deficiency. It aims to explore how this deficiency affects receptor development and cortical network function, potentially leading to new therapeutic targets.
NMDA receptor (NMDAR) dysfunction has been identified in multiple genetic causes of autism and related neurodevelopmental disorders. I recently showed that loss of Mecp2, the cause of Rett syndrome and some cases of autism, differentially affects NMDAR development at cortical synapses on specific cell-types: slowing down the development in excitatory pyramidal neurons and accelerating the maturation in parvalbumin-positive (PV) inhibitory interneurons.
Genetic manipulation of NMDAR expression in…
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