CORDIS Project
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This project investigates the replication mechanisms of nidoviruses, including coronaviruses and arteriviruses, to understand their genome diversity. It aims to characterize viral enzymes that could serve as targets for drug development.
Nidoviruses are an intriguing group of +RNA viruses, whose diverse genome sizes (11-41 kb) reflect a long history of adaptation to suit specific niches.
They remain mostly neglected, with the exception of the large-genome Coronaviridae (CoV) family (32 kb), which includes the notorious human pathogen SARS-CoV-2.
At the other end of the size-spectrum is the small-genome Arteriviridae (ArV) family (11 kb), an understudied group of prevalent, animal-infecting pathogens.
Viral replication is mediate…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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