CORDIS Project
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This project investigates how metabolism influences the fate of adult stem cells through cell-to-cell interactions and the geometry of their environment. By analyzing metabolic pathways and developing artificial niches, the research aims to enhance understanding of stem cell behavior and improve future cellular therapi…
Tissue renewal by adult stem cells is regulated by a multitude of cell intrinsic and extrinsic mechanism, which jointly guide decisions between stem cell self-renewal and differentiation.
Change between these two cellular fates is considered to result from transcriptional events that sequentially alter the function of the whole cell including its metabolism.
However, recent findings by us and others demonstrate that metabolism can actually actively influence cell fate.
Moreover, metabolites can…
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