CORDIS Project
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This project investigates a novel approach to Targeted Protein Degradation by directly targeting proteins for degradation without relying on ubiquitination. The goal is to develop new therapeutic strategies for cancer treatment by expanding the range of targetable proteins.
The ubiquitin-proteasome system (UPS) is crucial for maintaining diverse cellular functions through the selective degradation of proteins.
Targeted Protein Degradation (TPD) has emerged as an innovative therapeutic strategy that harnesses the UPS to selectively degrade disease-causing proteins. A major advancement in TPD is the use of proteolysis-targeting chimeras (PROTACs), small molecules that bind both an E3 ligase (E3) and the target protein, to induce ubiquitination and subsequent degradat…
BAR ILAN UNIVERSITY
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