CORDIS Project
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This project investigates how host cells use their cytoskeleton to fight off bacterial infections, focusing on the interactions between Mycobacterium marinum and the cytoskeleton in zebrafish. By utilizing advanced genome editing and microscopy, it aims to enhance our understanding of immune responses and develop strat…
Cell-autonomous immunity is the ability of a host cell to eliminate an invasive infectious agent.
Recent work has shown that components of the cytoskeleton have a major role in cell-autonomous immunity and control of bacterial infection.
The Mostowy group has shown that some intracellular bacteria, including Shigella flexneri and Mycobacterium marinum, can escape from phagosomes and invade the host cell cytosol where they interact with cytoskeleton components to form actin tails or be entrapped…
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