CORDIS Project
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This project explores the mechanisms of neuronal death in motor neuron diseases by investigating the role of the survival of motor neuron protein. It aims to understand how deficiencies in this protein lead to selective neuronal vulnerability, using advanced genetic tools and models.
The mechanisms behind neuronal death in different motor neuron diseases (MND) remain unknown.
These MNDs include the devastating spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). A fascinating question in neurodegeneration research is why mutations in ubiquitously expressed genes result in the selective death of a specific neuronal subtype.
The ubiquitously expressed and conserved survival of motor neuron (SMN) protein receives its name because its deficit results in MN dege…
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
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