CORDIS Project
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This project investigates the regulatory mechanisms of 3' untranslated regions in mRNA, particularly in brain cells. It aims to understand how these mechanisms contribute to neurodegenerative diseases like motor neuron disease through alternative polyadenylation and mRNA stability.
3' untranslated regions (3' UTRs) serve as a key platform in the RNA regulatory network that controls mRNA translational efficiency, localisation and stability.
Of all human cell-types, brain-specific isoforms have the longest 3' UTRs and therefore their regulation is likely to be most complex.
Moreover, mutations perturbing the mRNA secondary structure and sites of mRNA-miRNA interactions can lead to diseases such as neurodegeneration.
Isoforms of variable 3' UTRs are engendered by alternative…
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