CORDIS Project
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This project investigates the unique timing of human cortical neuron maturation compared to other species, focusing on the role of mitochondria and metabolism in this process. By exploring molecular differences, the research aims to enhance understanding of human brain development and its implications for neural evolut…
Human brain development is characterized by a prolonged timing of maturation of cortical neurons compared with other species.
The resulting ‘neoteny’ may constitute a key evolutionary mechanism enabling the exceptional gain of complexity of human brains compared to other animals.
However the molecular mechanisms underlying human neuronal neoteny, and its impact on circuit function, are largely unknown.
We previously discovered that human cortical neurons transplanted in the mouse cortex develop…
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