CORDIS Project
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This project focuses on the regulation of self-renewal in neural stem cells, particularly in Drosophila. It aims to uncover how disruptions in this process can lead to brain tumors by analyzing the transcriptional networks involved in stem cell differentiation.
The aim of this proposal is to understand how self-renewal is controlled in neural stem cell lineages and how defects in this process can lead to the formation of brain tumors in model organisms.
The system we use are Drosophila neuroblasts, stem cell like progenitors in the developing fly brain that undergo repeated rounds of asymmetric cell division.
During each division, protein determinants called Numb, Prospero and Brat are segregated into one of the daughter cells where they stop self-rene…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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