CORDIS Project
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This project investigates the behavior of neural stem cells in the adult brain, focusing on their activation and differentiation into neurons. It aims to understand how physiological states influence stem cell dynamics and neurogenesis, potentially informing treatments for neurological conditions.
In the adult mammalian brain, neural stem cells (NSCs) residing in the ventricular-subventricular zone (V-SVZ), give rise to new olfactory bulb neurons and glia throughout life.
Adult V-SVZ NSC are highly heterogeneous.
Stem cells co-exist in quiescent and activated states and reside in regionally-distinct V-SVZ domains and produce different subtypes of olfactory bulb neurons and glia.
However, whether this heterogeneity is due to intrinsic fate commitment or whether it is dynamically responsive…
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