CORDIS Project
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This project explores how neurons sort and transport proteins to their axonal regions, challenging existing models of protein distribution. By identifying new sorting pathways and mechanisms, it aims to enhance our understanding of neuronal function and its implications for human health.
Neuronal development and function rely on the polarized distribution of organelles and transmembrane proteins (cargoes) across their somatodendritic and axonal domains.
However, it is unknown how organelle organization regulates the polarized sorting of transmembrane proteins to ensure proper neuronal function.The classical model for sorting of newly synthesized transmembrane proteins to the plasma membrane (PM) follows the biosynthetic pathway via the rough endoplasmic reticulum (ER) and Golgi,…
UNIVERSITEIT UTRECHT
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