CORDIS Project
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This project develops a novel brain-machine interface using sonogenetics to control neuronal activity in large primate brains through ultrasound. By optimizing mechanosensitive proteins, it aims to achieve precise neural modulation, potentially offering new treatments for neurological disorders.
Brain-machine interfaces are classically based on multi-electrode arrays.
Optogenetics has revolutionized this ability to control neuronal activity through ectopic opsin expression but its application to large brains remains limited because of tissue light absorption and scattering.
Ultrasound waves have been proposed for remote neuromodulation, but this approach has remained restricted to low-frequency excitation, to prevent brain tissue overheating, at the expense of spatial resolution.
The ex…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Paris
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Italy, Milano
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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