CORDIS Project
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This project explores the diversity of ribosomes in neurons and their role in local protein synthesis. By examining how ribosome composition affects translation in response to synaptic activity, the research aims to deepen our understanding of neuronal plasticity.
The ability of the nervous system to respond adaptively relies on modifications to existing proteins as well as changes in gene transcription and mRNA translation.
It is now clear that synapses possess the capacity for local protein synthesis, owing to the localization of ribosomes and mRNAs within dendrites.
There is emerging interest in the possibility that ribosomes, as cellular machines, are not as static as typically assumed- and may be heterogeneous in composition and specialized for parti…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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