CORDIS Project
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This project focuses on identifying the neuronal circuits responsible for locomotion in mammals, specifically through glutamatergic neurons in the spinal cord. Techniques like RNA sequencing and optogenetics will be employed to understand how these circuits generate movement.
Locomotion is an essential motor act that for the most part is controlled by neuronal circuits in the spinal cord itself, called central pattern generators (CPGs), although their activity is turned on from centers in the brainstem.
Understanding the operation of CPG circuits in mammals has been a significant challenge to neuroscientists over the last 50 years.
The CPG for walking generates rhythm, as well as the precise patterns of muscular activity.
The neural assembly that is directly involved…
KAROLINSKA INSTITUTET
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