CORDIS Project
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This project focuses on developing advanced magnetic resonance imaging techniques to track brain changes in lysosomal storage diseases. By quantifying brain metabolites and assessing microstructural deficits, it aims to improve understanding of these diseases and evaluate new treatments that can bypass the blood-brain…
Continuing development of novel brain treatments, which bypass blood-brain barrier, further emerges the need to establish prognostic magnetic resonance (MR) markers to track progressive brain alteration in lysosomal storage diseases (LSD).
Excessive intracellular accumulation of lysosomal substances such as glycosaminoglycans in mucopolysaccharidosis (MPS), globotriaosylceramide in Fabry disease and glycocerebroside in Gaucher disease (GD) triggers multi-organ malfunctioning and significant dama…
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