CORDIS Project
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This project investigates the mechanical forces involved in neural tube closure, aiming to create a detailed map of these forces in living chick embryos. By using advanced bioprinting techniques, it seeks to enhance understanding of the coordination between different embryonic tissues, potentially leading to new strate…
Failure of neural tube closure causes neural tube defects (NTDs), which continue to affect 1:1,000 births in Europe.
Successful closure requires poorly understood coordination of cellular force-generating mechanisms in different embryonic tissues.
By adopting a novel bio-engineering approach, I aim to generate the first spatiotemporal map of mechanical forces in neural tube closure.
This unified biomechanical understanding of morphogenesis will provide a step-change in our interpretation of gene…
UNIVERSITA DEGLI STUDI DI PADOVA
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