CORDIS Project
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This project focuses on developing a drug candidate that mimics glial cell line-derived neurotrophic factor to treat Parkinson's disease. It aims to enhance neuron survival and alleviate both motor and non-motor symptoms associated with the disease.
PD is the most common age-related neurodegenerative disorder that is characterized by four pathognomonic hallmarks: 1) motor and non-motor deficits; 2) progressive loss of nigrostriatal dopamine neurons; 3) pathological aggregates of the α-synuclein (α-syn) protein; 4) neuroinflammation and oxidative stress.
There is no single treatment currently available (or being tested) that can affect mechanisms of the disease, promote regeneration or at least protection of dopamine (and other affected neur…
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