CORDIS Project
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This project investigates the regulation of cryptic splice sites in RNA, particularly in the brain, to understand their role in neuronal differentiation and diseases like amyotrophic lateral sclerosis. It employs experimental and computational methods to explore how RNA binding proteins influence splicing during brain…
A recent era of RNA research discovered complex RNA regulatory networks that involve RNA binding proteins (RBPs) and RNA.
These networks are particularly dynamic and complex in the central nervous system, and can lead to neurologic diseases if deregulated.
The host lab studies the regulatory networks that control alternative splicing in the brain.
Recently, the lab identified thousands of cryptic splice sites that are bound by the spliceosome, but do not lead to active splicing in the adult brai…
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