CORDIS Project
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This project investigates the role of centrosomes in neural development, focusing on RNA-binding proteins and their impact on neuronal migration disorders. It aims to understand how centrosome composition changes during neuronal development and to explore potential therapeutic interventions.
The centrosome is a crucial cellular organelle involved in many functions especially during development where it acts to regulate key processes, such as cell division, cilia formation and migration.
While many mutations in centrosome-associated proteins lead to diseases often predominantly affecting the brain, the basis for this specificity is in most cases not known.
Likewise, basic aspects of centrosome biology, such as the role of RNAs at the centrosome, are largely unknown.
Our recent discov…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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