CORDIS Project
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This project investigates the migration and integration of specific inhibitory neurons in human brain development, focusing on late-born neurons from the caudal ganglionic eminence. Using advanced organoid models, it aims to uncover genetic factors influencing these neurons' migration and their implications for neurode…
The development of cortical neural networks requires the migration and integration of ventrally-born inhibitory neurons (INs).
Many diverse IN subtypes are regionally and temporally specified throughout development, but late-born INs derived from the CGE have recently received increased attention due to their expansion in humans and strong associations with neurodevelopmental disorder (NDD) pathogenesis.
Recent studies have found that CGE INs form distinct migratory streams late in gestation and…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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