CORDIS Project
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This project investigates how neurons manage damaged proteins and organelles through a process called secretory autophagy. By using human-derived neurons, it aims to uncover the mechanisms behind this process and its implications for neurodegenerative diseases like Alzheimer’s.
Neurons transmit information by connecting with other neurons over long distances through their dendrites and axons.
Repeated stimulation places a high metabolic demand on these cells, leading to the accumulation of defective organelles and protein aggregates.
To maintain protein homeostasis, neurons rely on constitutive autophagy to remove these damaged proteins and organelles from their dendrites and axons, targeting them for degradation.
However, it is becoming increasingly clear that neurons…
UNIVERSITEIT UTRECHT
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