CORDIS Project
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This project investigates how glial cells in the nervous system can be reprogrammed into neurons, focusing on the molecular mechanisms involved in this conversion. By utilizing specific reprogramming factors and advanced sequencing techniques, the research aims to enhance our understanding of cell identity transformati…
Direct lineage reprogramming of cell identity in the nervous system offers the prospect of remodelling diseased brain circuits.
Recent years have provided evidence for the possibility of converting brain glia into neurons in vivo.
This may eventually allow to regenerate neurons that have degenerated as a consequence of injury or disease.
Yet, the process by which glial cells give up their original identity and adopt a neuronal fate remains by large enigmatic.
Moreover, the knowledge of molecular…
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