CORDIS Project
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This project investigates the role of GSK-3 kinases in the formation and maintenance of synapses in the brain, particularly in relation to cognitive decline in aging and neurodegenerative diseases. It aims to develop inhibitors to target these kinases and assess their effects on neuronal plasticity and degeneration.
Neuronal circuits in mammalian brain act predominantly via excitatory synapses on dendritic spines.
Formation of new spines in adult brain constitutes the structural basis of neuronal plasticity.
The underlying molecular mechanisms remain largely unknown but depend essentially on kinase-dependent signalling pathways.
Final formation of synapses on spines depends on dynamic interactions of microtubuli and actin-filaments that are also controlled by kinases.
Deterioration of these processes to dif…
KATHOLIEKE UNIVERSITEIT LEUVEN
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Israel, Tel Aviv
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Germany, MUNCHEN
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
TECHNISCHE UNIVERSITAT DARMSTADT
Germany, Darmstadt
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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