CORDIS Project
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This project aims to improve the understanding of tau protein spread in Alzheimer's disease by developing a patient-specific network model. The model will help enhance patient stratification in clinical trials, addressing the challenges posed by the disease's heterogeneity.
Alzheimer’s disease (AD) has far-reaching societal and economic consequences, emphasizing the urgent need for effective treatment solutions.
However, to date, over 99% of AD clinical trials have failed.
Inadequate patient stratification is a key contributing factor due to the enormous clinical and pathological heterogeneity in AD. AD is characterized by the aggregation of pathogenic proteins, with tau aggregates being a key player.
Tau-related pathological processes lead to synaptic dysfunction,…
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