CORDIS Project
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This project investigates the role of Neutrophil Extracellular Traps (NETs) in thrombosis, focusing on how specific enzymes degrade these structures in the body. By studying genetically modified mice, it aims to uncover new therapeutic targets for antithrombotic treatments.
Thrombosis is a major cause of morbidity and mortality emphasizing the need for new antithrombotic therapies.Recently, a novel pro-thrombotic mechanism was uncovered:
Neutrophil Extracellular Traps (NETs).
Neutrophils, the chief cells of the innate immunity, release DNA fibers during thrombosis.
These extracellular DNA filaments form web-like structures known as NETs, which provide a scaffold and stimulus for thrombus formation in vitro and in vivo.
Moreover, NETs are associated with thrombo…
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
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