CORDIS Project
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This project investigates how neutrophil extracellular traps (NETs) contribute to blood vessel damage during sepsis. By studying specific proteases involved in this process, the research aims to identify new therapeutic targets to mitigate organ failure associated with sepsis.
Every year over 400.000 EU citizens suffer from sepsis and every third of them dies due to the severity of this systemic inflammation.
The mortality results from excessive neutrophil activation leading to vasculature malfunctioning and subsequent multiorgan failure.Recently, we (outgoing host) revealed that during bacterial sepsis neutrophils activated by platelets release NETs (neutrophil extracellular traps) that trap and kill bacteria but this occurs at the expense of injury to endothelium (N…
KATHOLIEKE UNIVERSITEIT LEUVEN
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