CORDIS Project
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This project investigates the role of tiny exons, known as microexons, in different cell types, particularly focusing on their regulation by splicing factors Srrm3 and Srrm4. It aims to understand how these factors influence microexon expression in the brain, pancreas, and retina, and how misregulation may lead to dise…
Neural microexons are a paradigmatic example of a cell type-specific transcriptomic program.
Microexons are tiny exons that we revealed to have striking neuronal specificity established by their master splicing regulator Srrm4, which activates them during neuronal differentiation.
However, our unpublished data challenge this on/off regulatory and functional paradigm.
We found that a related paralog, Srrm3, is lowly but significantly expressed also in endocrine pancreas and, together with Srrm4,…
UNIVERSIDAD POMPEU FABRA
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