CORDIS Project
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This project aims to develop new methods for delivering nerve growth factor to the brain as a potential treatment for Alzheimer's disease. It focuses on overcoming the blood-brain barrier to improve therapeutic outcomes and enhance cognitive functions in affected individuals.
Alzheimer’s disease (AD) is a neurodegenerative disease affecting the aged population and is projected to increase 3-fold in the next 30 years.
Treatment options in AD are limited due to complex pathological processes and the blood-brain barrier (BBB), which restrict entry molecules into the brain. A finding in AD is the loss of cholinergic neurons.
Tropomyosin receptor kinase A (TrkA) and its substrate, the nerve growth factor (NGF), are involved in neuronal survival and have been evaluated in…
KOBENHAVNS UNIVERSITET
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