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NervAdapt investigates the metabolic adaptability of Schwann cells in the peripheral nervous system to enhance nerve repair after injury. The project aims to understand how these glial cells manage energy demands and interact with surrounding tissues, particularly under chronic stress conditions like diabetes and obesi…
The peripheral nervous system constitutes a prime example of a tissue with a strong regenerative potential.
Full recovery upon nerve trauma, however, is rare and usually fails in peripheral neuropathies - common, yet largely untreatable neurological disorders.
Nerve repair strictly depends on the orchestration of both nerve de- and regeneration by peripheral nerve glial cells, which need to overcome a substantial metabolic challenge in injury.
NervAdapt is based on the fundamental premise that S…
UNIVERSITAET LEIPZIG
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