CORDIS Project
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The NEMO project aims to develop an effective treatment for neonatal seizures caused by hypoxic ischaemic encephalopathy. It focuses on using bumetanide to modify GABA's action in the brain, with a goal of improving outcomes for affected infants through a large-scale clinical trial and tailored formulations.
Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in 2-3/1000 live births and is a major cause of both acute mortality and long-term neurodisability.
Seizures are the hallmark of HIE.
The clinical and electrographic seizure burden in babies with HIE can be considerable and is often not reduced by current antiepileptic drugs.
Phenobarbitone remains the first line drug for neonatal seizures despite the fact that it has limited efficacy.
Better treatments for neonatal seizures, particularly in…
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