CORDIS Project
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This project investigates the role of specific sensory neurons and mast cells in the development of atopic dermatitis, a common skin condition. It aims to uncover the interactions between these cells to identify new therapeutic targets for treatment.
Atopic dermatitis (AD) is a chronic skin inflammatory disease affecting 10-20% of children worldwide.
The etiology of AD is incompletely understood, but many elements (e.g., genetic, environmental or immune) are thought to contribute to the pathogenesis.
The skin is specifically enriched in mast cells (MCs) and innervated by a network of abundant sensory neurons.
New findings suggest that nociceptive sensory neurons (nociceptors) might regulate the development of immune responses.
Skin MCs also…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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