CORDIS Project
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This research investigates the role of the Nef protein in enhancing HIV-1 infectivity and its interaction with dynamin 2. Using a humanized mouse model, the study aims to clarify the significance of these mechanisms in HIV pathogenesis and their potential as targets for antiretroviral therapy.
The AIDS epidemic remains a worldwide emergency and the molecular mechanisms leading to the disease are not fully understood.
Nef is a gene product of primate lentiviruses crucial for virus replication in vivo and for AIDS progression.
The mechanisms supporting its pathogenic role remain undefined.
Among other activities, Nef enhances intrinsic virus infectivity, a feature well conserved and under selective pressure during disease progression.
While the significance of this activity in vivo is u…
UNIVERSITE DE GENEVE
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