CORDIS Project
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This research investigates the role of the Nef protein in HIV and other retroviruses, focusing on its multifunctionality and how it enhances viral infectivity. The goal is to uncover new strategies to combat viral infections.
Despite decades of intense research, HIV and other retroviruses retain still surprisingly obscure features, which we need to understand.
One of these features concerns Nef, a pathogenic factor of primate lentiviruses, crucial for virus replication and disease progression.
This is a challenging lentiviral molecule, because of its extraordinary multifunctionality.
If we know relatively well how Nef downregulates cell surface receptors, or activates T-cells and macrophages, we still do not understa…
UNIVERSITA DEGLI STUDI DI TRENTO
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