CORDIS Project
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This project focuses on developing a new synthetic method for creating daphniyunnine alkaloids, emphasizing a dual catalysis approach. It combines synthetic chemistry with biological evaluation to explore the anti-cancer properties of the resulting compounds, aiming to advance both scientific knowledge and practical ap…
This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the daphniyunnine family of alkaloids based on a novel dual organo / metal catalysed desymmetrization reaction of alkene-linked cyclohexanones as a key step, which will allow the rapid and efficient construction of the AB rings ready for subsequent advancement to the majority of the family members.
Evaluation of the anti-cancer biological activity of the different target molecules and late stage interme…
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