CORDIS Project
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This project aims to uncover how ubiquitin-like proteins regulate cellular functions through detailed structural studies of E3 ligases. By utilizing advanced imaging techniques and chemical biology tools, it seeks to understand the mechanisms of target regulation and the role of these proteins in various biological pro…
Post-translational modification by ubiquitin and ubiquitin-like proteins (UBLs) is a major eukaryotic regulatory mechanism.
Nonetheless, we have little understanding of the detailed mechanisms by which most E3 ligases mark specific targets with monoubiquitin, multiple ubiquitins or specific polyubiquitin chains, or of how UBL modifications transform the functions of their targets.
This proposal addresses both problems.
First, we will discover the structural mechanisms by which the UBL NEDD8 (…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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