CORDIS Project
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This project aims to understand how damaged DNA is repaired and how its spatial organization in the nucleus affects genome integrity. By studying double strand breaks in yeast, the research seeks to identify new mechanisms involved in DNA repair processes.
The eukaryotic genome is packaged into large-scale chromatin structures occupying distinct domains in the cell nucleus.
Nuclear compartmentalization has recently been proposed to play an important role in genome stability but the molecular steps regulated remain to be defined.
Focusing on Double strand breaks (DSBs) in response to which cells activate checkpoint and DNA repair pathways, we propose to characterize the spatial and temporal behavior of damaged chromatin and determine how this affec…
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