CORDIS Project
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This project focuses on the role of NEDD8, a ubiquitin-like molecule, in regulating cellular processes and nucleolar function. By identifying NEDD8-modified proteins, the research aims to uncover its significance in cell growth and potential therapeutic targets for cancer treatment.
Ubiquitin and ubiquitin-like molecules (Ubls) such as SUMO and NEDD8 regulate myriad of biological processes. NEDD8 was discovered as one of 10 genes that are down regulated in mice brains during development.
Amongst the family of Ubls, NEDD8 has the highest homology and identity to ubiquitin, but a distinct conjugation pathway exists that leads to the covalent conjugation of NEDD8 to substrate proteins.
Genetic experiments in plants, S. pombe, Drosophila, C. elegans, and mice, have demonstrated…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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