CORDIS Project
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The NaviFlu project aims to improve our understanding of how seasonal influenza viruses evolve. By creating prolonged human infections in a lab setting, it seeks to identify the various evolutionary pathways of the virus, enhancing our ability to predict its changes and improve vaccine design.
Seasonal influenza viruses re-infect us repeatedly, escaping antibody recognition, due to the evolution of the virus itself.
Being able to predict when and how the virus will evolve would be transformative for influenza virus control.
Problematically, we have only observed one of the likely many possible routes of virus evolution.
We do not know how many viable routes may have existed or about the repeatability of the observed evolution.
These knowledge gaps limit the predictability of influenza…
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