CORDIS Project
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This project develops targeted drug delivery systems using biodegradable antibody-drug conjugates aimed at macrophages. The focus is on treating nonalcoholic steatohepatitis by enhancing the efficacy of glucocorticoids while minimizing systemic side effects.
Macrophages play a key role in inflammatory diseases.
One of the goals of the TROJA ERC program has been to explore drug targeting via the haemoglobin scavenger receptor CD163, which has a high and exclusive expression in macrophages.
We have now developed new biodegradable anti-CD163 antibody-drug conjugates by linking drugs directly to anti-CD163 antibody and by encapsulating drugs in liposomes with anti-CD163 antibodies linked to the surface.
The CD163-targeting technology has been proven in…
AARHUS UNIVERSITET
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