CORDIS Project
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This research project investigates how nascent peptides can inhibit their own synthesis during protein translation in bacteria. It aims to decode the mechanisms behind this process, which could lead to advancements in gene regulation and antibiotic development.
During the translation of genetic information into protein by the ribosome, nascent peptides occasionally inhibit their own synthesis by interacting with the exit tunnel of the large ribosomal subunit.
Known as nascent chain-mediated translational arrest, this process depends primarily upon the amino acid sequence of the arrest peptide.
However, it can also rely upon the sensing of a low molecular weight ligand by the ribosome nascent chain complex, explaining its use for metabolite-dependent ge…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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