CORDIS Project
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This research focuses on alternative splicing in the nervous system, particularly how it affects neuronal development. It aims to understand the roles of specific protein isoforms in regulating axon development and intracellular transport.
Alternative splicing is the process by which multiple mRNA isoforms can be generated from one gene by differential usage of alternative exons in the mature mRNA.
It is a major mechanism by which higher vertebrates generate functional complexity of their proteome.
Approximately 95% of human genes are alternatively spliced and this process is especially abundant in the nervous system and crucial for proper regulation of neuronal gene expression.
Evidence comes from identification of mutations d…
KOC UNIVERSITY
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