CORDIS Project
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This project investigates the mechanisms of calcium ion signaling in neurons, focusing on the activation of large conductance calcium-activated potassium channels. It combines genetics and electrophysiology to understand how these channels function within calcium nanodomains.
In neurons, sites of Ca2+ influx and Ca2+ sensors are located within 20-50 nm, in subcellular “Ca2+ nanodomains”.
Such tight coupling is crucial for the functional properties of synapses and neuronal excitability.
Two key players act together in nanodomains, coupling Ca2+ signal to membrane potential: the voltage-dependent Ca2+ channels (VDCC) and the large conductance Ca2+ and voltage-gated K+ channels (BK). BK channels are characterized by synergistic activation by Ca2+ and membrane depolariza…
UNIVERSIDAD DE LA LAGUNA
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