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NanoMechShape investigates how animal cell shape is regulated by forces, focusing on the actin cortex. The project aims to understand the mechanisms behind cell deformations and transitions in actin architecture, bridging molecular processes with cell-scale behaviors.
Precise control of shape is key to cell physiology, and cell shape deregulation is at the heart of many pathologies.
As cell morphology is controlled by forces, studies integrating physics with biology are required to truly understand morphogenesis.
NanoMechShape will take such an interdisciplinary approach to investigate the regulation of animal cell shape.In animal cells, actin networks are the primary determinants of shape.
Most cell shape changes fall into two categories: 1) those driven by…
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