CORDIS Project
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This project develops a novel therapeutic strategy for glioblastoma treatment by combining radiation therapy with immunotherapy. It focuses on reprogramming tumor-associated macrophages to enhance treatment efficacy and improve patient outcomes.
In glioblastoma (GBM), intrinsic and environmental factors are limiting the efficacy of radiation therapy (RT) and immunotherapy.
These factors include intrinsic cancer cells resistance, hypoxia, and the presence of immunosuppressive cells such as tumorassociated macrophages (TAMs).Considering these current limitations for RT efficacy and the specific deleterious role of TAMs in GBM, I designed an original therapeutic strategy combining enhanced RT and TAMs reprogramming with toll-like receptors…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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