CORDIS Project
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This project develops advanced bionanotechnology vaccine platforms to enhance immune responses against chronic viral infections, specifically hepatitis B. It focuses on creating small nanoparticles that activate immune cells in lymph nodes and mucosal tissues for more effective DNA vaccination.
We have recently developed a bionanotechnology approach to vaccination (Reddy et al., Nature Biotechnology, 25, 1159-1164, 2007): degradable polymeric nanoparticles are designed that: (i) are so small that they can enter the lymphatic
circulation by biophysical means; (ii) are efficiently taken up by a large fraction of dendritic cells (DCs) that are resident in the lymph node that drains the injection site; (iii) activate the complement cascade and provide a potent, yet
safe, activation signal…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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