CORDIS Project
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This project explores the structural mechanisms that govern the specific functions of Ras-like GTPases, which are vital for cellular processes. By examining how these proteins interact with membranes, the research aims to uncover new insights into their activity and potential therapeutic targets for diseases like cance…
Small GTPases of the Ras superfamily, a major class of signalling proteins, control critical cellular functions, such as proliferation, differentiation, migration and trafficking.
Their misregulation is associated with severe diseases, such as cancer or neurodegenerative diseases.
More than 150 Ras-like GTPase are known, which are divided into four major subfamilies, each containing between 22 to 63 structurally related, but functionally distinct isoforms. A fundamental unresolved biological que…
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